• Rucaparib (AG-014699): New Insights Into PARP1 Inhibition...

  2025-09-23

  Explore the unique role of Rucaparib (AG-014699, PF-01367338) as a potent PARP1 inhibitor in DNA damage response research, with new perspectives on apoptotic pathways linked to RNA Pol II inhibition. This article highlights its application in radiosensitization and innovative cancer biology research.

• 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole: Mechanisms...

  2025-09-22

  Explore the molecular mechanisms and research applications of 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB), a potent transcriptional elongation inhibitor and CDK inhibitor, in HIV transcription inhibition and cell cycle regulation. This article provides a rigorous review of DRB's action on RNA polymerase II and its utility as an antiviral agent against influenza virus.

• Vardenafil HCl Trihydrate: Advancing Proteoform-Aware PDE...

  2025-09-19

  Explore how Vardenafil HCl Trihydrate, a potent and selective PDE5 inhibitor, enables rigorous investigation of smooth muscle relaxation and cGMP signaling in a proteoform-specific context. This article discusses practical strategies for integrating proteomics with functional assays.

• Gastrin I (human): Advanced Applications in Gastrointesti...

  2025-09-18

  Explore the multifaceted role of Gastrin I (human) as a gastric acid secretion regulator and CCK2 receptor agonist in cutting-edge gastrointestinal physiology studies, including its integration with human stem cell-derived intestinal organoid models.

• br Acknowledgments This work was supported by Grant in aid

  2025-03-03

  

  Acknowledgments This work was supported by Grant-in-aid for Scientific Research (S) (20229008) (to T.K.), Targeted Proteins Research Program (to T.K.), the Global COE Research Program (to T.K.) and Translational Systems Biology and Medicine Initiative (to T.K.) from the Ministry of Education, Cul

• The Cebu Longitudinal Health and Nutrition Survey CLHNS geno

  2025-03-03

  

  The Cebu Longitudinal Health and Nutrition Survey (CLHNS) genome-wide association study investigated the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women. Adiponectin was strongly associated with three genetic positions: the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), ne

• br A novel therapeutic strategy based on

  2025-03-03

  

  A novel therapeutic strategy based on the APN and obesity paradoxes As shown above, the relationship of the serum APN concentration with health and disease states shows an inverted-U correlation, suggesting that moderate concentrations of serum APN are beneficial (Fig. 3). Given that both hypo- a

• Neural progenitor cells NPCs are self

  2025-03-03

  

  Neural progenitor cells (NPCs) are self-renewing, multipotent cells that are capable of differentiating into neurons, astrocytes and oligodendrocytes. NPCs are activated in response to a variety of pathological states in neurodegenerative diseases such as Parkinson’s disease and multiple sclerosis,

• H4 receptor antagonist br Expression of ADK in the normal

  2025-03-03

  

  Expression of ADK in the normal brain In adult brain, ADK is primarily expressed in astrocytes. Immunocytochemical analysis of adult rat and mouse H4 receptor antagonist revealed predominant astrocytic expression throughout the hippocampus and cortex. Two isoforms of ADK have been identified in

• Our studies also reveal the normal functional roles of the

  2025-03-03

  

  Our studies also reveal the normal functional roles of the MIR. Interaction between the MIR loop and the N-terminal α helix nucleates conformational maturation of AChR subunits, thereby promoting assembly of mature AChRs [52], [55]. This interaction in homologous parts of all AChR subunits appears t

• As the effects of baclofen on primary

  2025-03-01

  

  As the effects of baclofen on primary afferent activity are not reproduced by GABAA receptor agonists like muscimol and isoguvacine, this ionotropic receptor may play minimal role in the modulation of primary afferent activity. However, it is important to note that post-synaptic GABAA receptors rema

• The structural analysis of the

  2025-03-01

  

  The structural analysis of the ASK1 activation segment, which was not phosphorylated in the crystal structure, showed interactions mimicking those found in activated kinases. In addition, the isolated unphosphorylated ASK1-CD is active and able to autophosphorylate itself at three sites, Thr813, Thr

• Autophagy is a self protecting cellular catabolic pathway th

  2025-03-01

  

  Autophagy is a self-protecting cellular catabolic pathway that degrades and recycles cytoplasmic contents for the maintenance of cellular homeostasis (Shao et al., 2016b). Macrophage autophagy plays an essential role in atherosclerosis by safeguarding HBC against oxidative stress, reducing apoptosi

• The isoelectric point of CL

  2025-03-01

  

  The isoelectric point of CL-ARG was determined by native IEF at a Reparixin L-lysine salt gradient in the range (3–10) using standard protein markers with known isoelectric points. Native IEF reveals the presence of only one major band for CL-ARG with a slightly neutral-basic pI value of about 7.7.

• Numerous epidemiological studies document fewer cardiovascul

  2025-03-01

  

  Numerous epidemiological studies document fewer cardiovascular events and increased survival of non-CKD individuals treated with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARBs) [8], [9]. By contrast, there are few studies of cardiovascular benefits of interruption

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