• Our finding that activating DDR variants are a cause

  2020-04-09

  

  Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho

• The possibility that a carboxyl group attached to the or

  2020-04-09

  

  The possibility that a carboxyl group attached to the or position of an -arylaminomethylenemalonate ester would lead to increased selectivity for DHODH has been tested and found not to be the case. Indeed, reduced selectivity compared with the corresponding ester is observed and is attributed to a

• br Ubiquitin Capture by the Mobile APC RING Domain Contribut

  2020-04-09

  

  Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the Ramelteon correlates with processivity o

• Moreover recent structural studies of VEEV nsP

  2020-04-09

  

  Moreover, recent structural studies of VEEV nsP2pro in complex with E-64d revealed an important molecular interaction at the interface of two subdomains. In this structure, Asn475 which is in polar contact with carbonyl oxygen of Asp507 of the protease subdomain makes an H-bond with Arg662 of the MT

• br Acknowledgements br Introduction Three

  2020-04-09

  

  Acknowledgements Introduction Three structurally related fungal metabolites have been isolated from chloroform extracts of submerged rice cultures of Aspergillus terreus 23-1 from stored unhulled rice in Taiwan; these were named territrems A–C to indicate their biological origin (A. terreus) a

• Once sufficient single stranded DNA ssDNA has been exposed a

  2020-04-09

  

  Once sufficient single-stranded DNA (ssDNA) has been exposed at origins, synthesis of leading and lagging strands is initiated by the DNA polymerase α-primase complex (Pol α). Lagging-strand synthesis requires repeated cycles of Pol α-dependent priming and subsequent primer extension by Pol δ. Pol α

• Targeting both PARP and DHODH for anti

  2020-04-09

  

  Targeting both PARP-1 and DHODH for anti-cancer therapy would certainly be beneficial as these enzymes share a common role in the DNA replication and repair mechanisms which are involved in the hyper-proliferation of cancer cells. Since benzimidazole-containing compounds have been reported to show

• Our previous studies have demonstrated that the DDR discoidi

  2020-04-09

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• Materials and methods Cell culture and receptor gene transfe

  2020-04-08

  

  Materials and methods Cell culture and receptor gene transfection. PC12 Poziotinib were purchased from the Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, China. The cDNA for mouse CysLT1 or CysLT2 receptor (mCysLT1 and mCysLT2, subcloned into pcDNA3.0) was kindly gifted by Profes

• br Conflict of Interest br Statement of

  2020-04-07

  

  Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho

• Because of the complexity of DNA

  2020-04-07

  

  Because of the complexity of DNA damage and its repair, several pathways are candidates in HN2-induced DPC repair. Considering the 23kDa molecular weight of MGMT, NER may be ineffective for MGMT-adduct removal. This presumption is supported by that the mRNA level of ERCC1, a core gene in NER pathway

• Consistent with prior reports this

  2020-04-07

  

  Consistent with prior reports, this study also found the level of 11 cytokines (MIF, IL-1Ra, CTACK, M-CSF, Basic FGF, VCAM-1, SDF-1α, IL-8, IL-16, PDGF-β, and GRO-α) significantly decreased in the sera of adult HFMD patients in comparison with controls. MIF is a pro-inflammaory cytokine that is asso

• br Introduction Rhabdomyosarcoma RMS is

  2020-04-07

  

  Introduction Rhabdomyosarcoma (RMS) is a myogenic tumor that accounts for approximately 50% of all pediatric soft tissue sarcomas. Diagnostic criteria for RMS 5-Azacytidine on the validation of proteins of the skeletal muscle lineage, such as Desmin, MyoD or Myogenin [1]. RMS cells are persisten

• Uracil residues incorporated into DNA exist transiently sinc

  2020-04-07

  

  Uracil residues incorporated into DNA exist transiently since they are subject to removal by the multi-step uracil-initiated DNA r407 excision repair (BER) process [2], [14]. In E. coli, uracil-DNA BER is initiated by uracil-DNA glycosylase (Ung), which catalyzes the hydrolytic cleavage of the N-gl

• br Diseases which have been treated

  2020-04-07

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty MLN4924 derivatives of human insulin bound to HSA have applications in the treatment of diabetes while paclitaxel-H

14359 records 812/958 page Previous Next First page 上5页 811812813814815 下5页 Last page