• br Experimental br Declaration of interest br

  2021-05-14

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR CMK library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modified and elab

• No effect on the A production by secretase

  2021-05-14

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured EHT 1864 by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this concentration. γ-Se

• Daun02 Several studies suggest that the beneficial metabolic

  2021-05-14

  

  Several studies suggest that the beneficial metabolic effects of adiponectin in humans are primarily mediated by its HMW isoform. Increases in the ratio of HMW to total adiponectin, but not the total adiponectin level, correlated well with improved Daun02 sensitivity during treatment with the insul

• Damage of PE HD due

  2021-05-14

  

  Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o

• Although the presence of calcium in RHA P active site

  2021-05-14

  

  Although the presence of calcium in RHA-P active site is confirmed by the homology modeling, some additional observations can be made following the metal depletion and reconstitution experiments performed on RHA-Phis. EDTA-treated RHA-Phis recovers its activity in the presence of divalent cations su

• It is believed that emphysema

  2021-05-14

  

  It is believed that emphysema in smokers is mediated by proteases released from inflammatory GW9662 that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysematous lesions in exp

• br Abbreviations br Introduction br Collagen

  2021-05-14

  

  Abbreviations Introduction Collagen-induced DDR activation A key feature of DDRs is their ability to bind both fibrillar and non-fibrillar collagens (Shrivastava et al., 1997, Vogel et al., 1997). DDR1 and DDR2 recognize the GVMGVO (O, hydroxyproline) motif within fibrillar collagens I–III

• Similarly in the EAE model Chalmin et al previously

  2021-05-14

  

  Similarly in the EAE model, Chalmin et al. previously demonstrated that EBI2 and CH25H might be responsible for the efficient egress of differentiated Th17 cells from the draining lymph nodes [31]. As discussed above, in active EAE we did not find differences in EAE development and only the transfer

• Itch also known as astrophin interacting

  2021-05-13

  

  Itch, also known as astrophin-1 interacting protein-4 (AIP4), is a HECT domain-E3 ligase. It was discovered in 1998 in mouse coat color genetic studies which displayed the disruption caused by the Itch gene inducing a lethal autoimmune inflammatory condition. The substrates of Itch are transmembrane

• br Results br Discussion Many studies have shown that intrin

  2021-05-13

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific Cy3-dUTP type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous studi

• Given the structural similarity of BMAA to

  2021-05-13

  

  Given the structural similarity of BMAA to other amino acids, our hypothesis was that N-nitrosation of BMAA might result in a toxic alkylating agent, providing a previously unrecognised mechanism for BMAA action. Materials and methods Results and discussion We first examined whether chemical

• We demonstrated that cells expressing less DHODH

  2021-05-13

  

  We demonstrated that AP20187 expressing less DHODH were less sensitive to DHODH inhibitors regardless of their oncogenic status. Based on the proliferation speed of cells, Kant et al. (1989), showed that slow-growing squamous cell carcinoma was more sensitive to BQR than fast-growing murine leukemia

• br Materials and methods br Results br Discussion

  2021-05-13

  

  Materials and methods Results Discussion The present work demonstrates the functional role of DGAT2 in elevating the neutral lipid accumulation in engineered N. oceanica, which have aroused a great deal of interest in industrial scale biofuel production. Recently, there have been increasing

• RDH belongs to C family of

  2021-05-13

  

  RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,

• br Hypothesis on DDR protective

  2021-05-13

  

  Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci

14733 records 631/983 page Previous Next First page 上5页 631632633634635 下5页 Last page