• br Patients and methods br Results

  2021-05-07

  

  Patients and methods Results Table 1 shows relevant demographic and clinical characteristics of the 123 patients in the cohort. BAL fluid samples were obtained at a median of 172.5 days after allo-HSCT (range 3 days to five years). Discussion The definitive abandonment of traditional cultu

• Interestingly selective ETA blockade increased cutaneous blo

  2021-05-07

  

  Interestingly, selective ETA blockade increased cutaneous blood flow as measured by laser Doppler fluxmetry. This is a measure of total blood flow in the different vessels in the skin including venules, U0126 as well as arterioles. This finding is in accordance with the previous demonstration that

• br Experimental br Results and discussion On

  2021-05-07

  

  Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it notch signaling is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the con

• Mammalian cells contain significant amounts of a relatively

  2021-05-07

  

  Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids. This enzyme is called CoA-independent transacylase (CoA-IT), and transfers polyunsaturated moieties of 20–22 carbons, typical

• OxLDL down regulates eNOS and up regulates iNOS thereby

  2021-05-07

  

  OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial p-nitro-Cyclic Pifithrin-α mg [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example

• br Results br Discussion Mucosal barriers are

  2021-05-07

  

  Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune AZD6482 sale (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s are found in ly

• Two primary members of the TRIM family

  2021-05-07

  

  Two primary members of the TRIM family – TRIM5α and TRIM25 – function as antiviral effector and immune regulator, respectively. TRIM5α is one of the best characterized members of the TRIM family (both structurally and functionally) and reported to be an important ubiquitin-mediated regulator of a ma

• These studies established IAP proteins as dimeric RING E lig

  2021-05-07

  

  These studies established IAP proteins as dimeric RING E3 ligases, but did not account for the essential role of dimerization. In IAPs and related E3s, such as RNF4 and MDM2, dimerization not only depends on contacts from the core RING domain but also residues N- and C-terminal to the RING domain (B

• The yeast Rad p radiation sensitive also

  2021-05-07

  

  The yeast Rad6p (radiation sensitive 6, also called Ubc2) E2 ubiquitin-conjugating enzyme is a member of the highly conserved UBC proteins in eukaryotes (Xu et al., 2009). Rad6p is involved in several cellular processes, including DNA repair, transcriptional activation and silencing, histone ubiquit

• Our data supports the conclusion that the exonuclease

  2021-05-07

  

  Our data supports the conclusion that the exonuclease activity thought to be intrinsic to Artemis is not a component of the Artemis polypeptide. Many possibilities exist to explain the presence of the exonuclease activity in less-pure fractions of Artemis. It is possible that the exonuclease is simp

• cGAS has a central role in STING activation

  2021-05-07

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• Thymine glycol severely inhibits DNA synthesis by

  2021-05-07

  

  Thymine glycol severely inhibits DNA synthesis by replicative DNA polymerases and requires the action of specialized DNA polymerases for translesion synthesis (e.g. Ref. [26]). Eukaryotic and archaeal RNAPs were shown to pause after nucleotide insertion opposite TG [27,28]. Surprisingly, we found th

• Pol is responsible for the

  2021-05-07

  

  Pol ε is responsible for the bulk of leading-strand synthesis in vivo (Daigaku et al., 2015, Nick McElhinny et al., 2008, Pursell et al., 2007) and physically associates with CMG (Langston et al., 2014, Sengupta et al., 2013, Sun et al., 2015, Zhou et al., 2017). Furthermore, leading-strand synthesi

• In laboratory strains of Escherichia coli three

  2021-05-07

  

  In laboratory strains of Escherichia coli, three mechanisms of repair for alkylated bases are known. The first involves constitutively expressed Ogt and inducible Ada methyltransferases, directly removing methyl groups from O6-methylguanine (O6meG) and O4-methylthymine (O4meT) [1], [2], [3], [4]. In

• The preferences for source of FAs for DGAT and

  2021-05-06

  

  The preferences for source of FAs for DGAT1 and DGAT2 are related to their membrane topologies, subcellular locations, interactions with other proteins or organelles (discussed in the former section), and their differential expression, substrate specificities, and enzyme kinetics. According to UniPr

14415 records 614/961 page Previous Next First page 上5页 611612613614615 下5页 Last page