• Gap junctions mediate electrical coupling between cells by c

  2021-11-10

  

  Gap junctions mediate electrical coupling between cells by conducting direct ionic currents and thereby modulate their electrical activity (Hormuzdi et al., 2004). In the nervous system, electrical coupling organizes network activity by amplifying and synchronizing neuronal firing (Galarreta and Hes

• Until recently the mechanism of how

  2021-11-10

  

  Until recently the mechanism of how GSMs shifted γ-secretase cleavage was poorly understood. Today, building on the sequential cleavage model developed by Ihara and colleagues [14], there is evidence that GSMs act as processivity enhancers, and iGSMs as inhibitors of processivity [120]. At least for

• br Conflicts of interest br Acknowledgment br Introduction T

  2021-11-10

  

  Conflicts of interest Acknowledgment Introduction The Zoniporide dihydrochloride growth factor receptors (FGFRs) are a family members of receptor tyrosine kinase (RTK) that represent attractive therapeutic targets for anti-cancer therapy gaining more and more attention in recent years [1],

• The subcellular redistribution of some metabolic enzymes is

  2021-11-10

  

  The subcellular redistribution of some metabolic enzymes is dynamic and responsive to metabolic conditions. In the absence of glucose, Glucokinase (GK) is bound to its regulatory protein in the nucleus of the hepatocyte and translocates to the cytoplasm when sugar levels increase [12]. Muscle glycog

• br Methods br Acknowledgements We are grateful to

  2021-11-10

  

  Methods Acknowledgements We are grateful to Eric Olson for providing Yap/Taz floxed mice, and to members of the Epstein lab for helpful comments and advice. This work was supported by NIH R01 HL118768, R35 HL140018, the Cotswold Foundation and the WW Smith Endowed Chair to J.A.E. The Hippo

• Torin 2 br Conclusions In this study we report the genotype

  2021-11-09

  

  Conclusions In this study, we report the genotype frequencies for GSTT1, GSTP1, and GSTM1 in Jamaican children. The frequency of the null genotypes of GSTT1 and GSTM1 are similar to those of African-Americans in the US. The GSTP1 genotype frequency is closer to that of the African-American popula

• We addressed the role of GSNOR mediated T cell activation

  2021-11-09

  

  We addressed the role of GSNOR-mediated T-cell activation in HHcy-accelerated atherosclerosis in vivo by two mouse models. Generated for the first time, GSNOR-/-ApoE-/- double knock-out mice showed decreased atherosclerosis in aortic roots in response to HHcy. The specificity of GSNOR ablation in T

• Studies with GSNOR knockout mice reported decreased CD cells

  2021-11-09

  

  Studies with GSNOR knockout mice reported decreased CD4+ fccp and increased CD19+ cells (B-cell) in the blood [31] as well as demyelination, neurodegeneration, and neuropathic pain [29]. To understand the basis of these differences in immune function of GSNOR knockout mice and GSNO treated mice, we

• Through a large scale phylogenetic analysis of UDG superfami

  2021-11-09

  

  Through a large-scale phylogenetic analysis of UDG superfamily in more than 1000 completely sequenced genomes, it is shown that family 3 pcpt synthesis can be separated into two clades with the traditional family 3 SMUG1 as one of them (Fig. 1) [31]. UDG enzymes in another clade are present in euba

• In this study with the use of C

  2021-11-09

  

  In this study, with the use of 13C515N2-labeled glutamine, we observed that 13C515N2-labeled glutamine produces a wide range of NAAG isotopologues and its precursors: NAA and glutamate. The NAAG production from glutamine is consistently more elevated in MYC-ON lymphoma and OVCAR4 compared to MYC-OFF

• Polyunsaturated fatty acids PUFAs represent a class of lipid

  2021-11-09

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic STA-21 (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic acid (AA)

• (-)-Bicuculline methobromide To further implicate the role o

  2021-11-09

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 (-)-Bicuculline methobromide was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus o

• br Acknowledgements We thank the following individuals

  2021-11-09

  

  Acknowledgements We thank the following individuals for notable contributions to this work: Dr. Ruth Wood, Dr. Alan Watts, Dr. Casey Donovan, Andrea Suarez, Emily Nakamoto, Allison Apfel, April Banayan, and Jonathan Cheung. This study was supported by the National Institute of Health grants, DK10

• br Materials and Methods br Results br Discussion

  2021-11-09

  

  Materials and Methods Results Discussion In the present study, we investigated the postnatal expression of the two GABA receptor subunits, GABAAα1 and GABAB1, in order to determine the differential expression and regional distribution pattern of them between right and left hippocampi in the

• Stimulation of FPR by bacterial N formyl peptides induces

  2021-11-09

  

  Stimulation of FPR by bacterial N-formyl peptides induces basophil and mast AZ 10417808 sale release of immunogenic compounds such as histamine [21], [31]. Furthermore, we demonstrated that histamine plays a role in F-MITs-induced sepsis-like symptoms since cimetidine, a histamine H2-receptor antag

14440 records 509/963 page Previous Next First page 上5页 506507508509510 下5页 Last page