• Introduction The onset of uterine labor is the culmination

  2022-06-28

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• br Regulation of gonadotropins by GnRH GnRH is released

  2022-06-28

  

  Regulation of gonadotropins by GnRH GnRH is released from the hypothalamus, and its release pattern is known to be pulsatile. That is, the pulse frequency and amplitude of GnRH release vary physiologically during reproductive cycles in females, and differentially stimulate the production and rele

• Due to the therapeutic potential of

  2022-06-28

  

  Due to the therapeutic potential of GlyT1 inhibitors, numerous drug screening campaigns have been started - and are still going on - which aimed at the identification of compounds with biological activity at or affinity for this drug target. For characterization of biological activity at GlyT1, tran

• Finally the formation of a

  2022-06-28

  

  Finally, the formation of a regular network of fusion glycoproteins in their post-fusion state is not exclusive of vesiculovirus G. More or less regular networks have been also observed with other class III fusion glycoproteins such as pseudorabies gB [85] and several class II fusion glycoproteins [

• In response to oxidative stress in DM antioxidant

  2022-06-28

  

  In response to oxidative stress in DM, antioxidant defence systems are activated in β-cells. Glutathione (GSH) is one of the most abundant antioxidants and has been shown to be expressed at lower concentrations in patients with DM [12], [13]. Furthermore, plasma levels of glycine, which is a synthet

• SW033291 synthesis It is becoming increasingly apparent that

  2022-06-28

  

  It is becoming increasingly apparent that membrane lipids play a critical role in modulating and regulating protein function. For example, embedding the homologous SLC1 transporter GltPh in a POPE bilayer allowed a third Na+ binding site to be identified from MD simulations [42], and the binding ene

• Exendin-3 (9-39) amide Recently several dual GLP GIP recepto

  2022-06-27

  

  Recently, several dual GLP-1/GIP receptor agonists have been developed as a treatment of type II diabetes. These peptides can activate both the GLP-1 and the GIP receptor. Such dual receptor agonists are superior compared to single GLP-1 analogues such as liraglutide (Finan et al., 2013). Previously

• br Role of BKCa in Cardiovascular System br

  2022-06-27

  

  Role of BKCa in Cardiovascular System Perspective for BKCa Channels as Potential Target for Cardiovascular Diseases The intermediate conductance Ca-activated K+ channels (IKCa; KCa3.1, also known as SK4, IK, IKCa1, SMIK) were first discovered in erythrocytes by Gardos (1958) and then also fo

• In summary metagenome sequencing of paddy soil was performed

  2022-06-27

  

  In summary, metagenome sequencing of paddy soil was performed with 55.68 Gb sequences, and subsequent data mining was performed for functional profiles and metabolic pathways. Several GH family proteins, such as amylases, cellulases, xylanases, and galactosidases, were explored in the paddy soil met

• br Introduction The brain contains abundant fatty

  2022-06-27

  

  Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial cells, suggesting that fatty acids play a crucial role in d

• In the FARM motifs of

  2022-06-27

  

  In the FARM motifs of GGPPSs, hydrophobic 4064 are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase (GGPPS) act

• To discriminate the peripheral and

  2022-06-27

  

  To discriminate the peripheral and central involvement of FAAH in paracetamol action, we proposed a pharmacological strategy challenging the analgesic action of paracetamol observed in an inflammatory context with either a peripherally-restricted FAAH inhibitor (URB937, Clapper et al., 2010, Moreno-

• br Introduction It is well known that conventional cancer

  2022-06-27

  

  Introduction It is well known that conventional cancer treatment strategies, such as surgery, radiotherapy, and chemotherapy all have their own limitations, which lead to an unsatisfactory therapeutic effect. Under this situation, the combination of two or more therapeutic strategies has recently

• br Methods br Results We have previously used

  2022-06-27

  

  Methods Results We have previously used ß-hex assays in HeLa prostanoid receptors to study the role of lysosomal exocytosis on transition metal clearance and the effects of transition metals on lysosomal exocytosis [26], [29], [40]. ß-hex is a lysosomal enzyme, the delivery of which to the ex

• In neurons and neuroendocrine cells the productive fusion pa

  2022-06-27

  

  In neurons and neuroendocrine cells, the productive fusion pathway is thought to initiate with the Munc18-1/Syx1 complex (Ma et al., 2013, Hughson, 2013, Lai et al., 2017). The Munc13-1 MUN domain is able to catalyze opening of Syx1 (the transition from the Munc18-1/Syx1 complex to the SNARE complex

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