• Calcium entry through postsynaptic NMDARs

  2023-02-06

  

  Calcium entry through postsynaptic NMDARs activates intracellular signaling cascades including Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and calcineurin. The spatiotemporal abundance of this Ca2+/CaM complex determines the direction of synaptic plasticity, resulting in LTP (Malinow

• BMS-911543 Heart failure is a chronic syndrome

  2023-02-06

  

  Heart failure is a chronic syndrome in which the heart is unable of pumping an adequate supply of blood to meet the metabolic requirements of the body or generating the required elevated ventricular filling pressures to maintain output [34]. Despite considerable advances in the treatment of heart fa

• br Materials and methods br Results

  2023-02-01

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• The mitogen activated protein kinase MAPK plays

  2023-02-01

  

  The mitogen-activated protein kinase (MAPK) plays an important role in a variety of cell processes by controlling transcriptional or translational regulation [14]. There are three major MAPK family members that have been well characterized: extracellular signal-regulated kinase (ERK), c-Jun N-termin

• br Introduction Arginase deficiency is a

  2023-02-01

  

  Introduction Arginase deficiency is a rare metabolic disorder resulting from a loss of arginase 1 (ARG1), the final enzyme in the urea cycle, which is the major pathway for the detoxification of ammonia in terrestrial mammals. ARG1 is expressed most prevalently in hepatocytes and red blood cells.

• br Materials and methods br

  2023-02-01

  

  Materials and methods Acknowledgement This work was supported by the Beijing Natural Science Foundation (Grant no. 6151001), and the National Natural Science Foundation of China (Grant no. 31572516). Introduction Staphylococcus aureus is an important microorganism responsible for both clin

• mg115 br Steroidogenesis in the skin The synthesis of steroi

  2023-02-01

  

  Steroidogenesis in the skin The synthesis of steroid hormones takes place in many tissues of which the adrenal glands, ovaries, testis, placenta and mg115 are considered to be classical steroidogenic organs. Nevertheless, skin constitutes an important peripheral steroidogenic tissue. Steroidogen

• br Competing interests br Acknowledgments

  2023-02-01

  

  Competing interests Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2014R1A4A1071040). Introduction Mitochondria occupy an important position as mediators of

• Interestingly metabolic dysfunction is also observed in

  2023-02-01

  

  Interestingly, metabolic dysfunction is also observed in amyotrophic lateral sclerosis (ALS). Patients and mouse models of familial ALS exhibit higher levels of resting SP 141 expenditure and lower fat-free mass, indicating a hypermetabolic phenotype. Lim et al. (2012) found that reducing AMPK acti

• br Discussion The clinical course of

  2023-02-01

  

  Discussion The clinical course of our patient until May 2012 was rather typical of early onset AChR-MG. Later on, the pattern of the disease was more typical of MuSK-MG, as evidenced by the distribution of myasthenic weakness and the unprovoked exacerbations. The AL 8810 sale of MuSK-MG appears

• Fmoc-Ser-OH sale To date more than different mutations in th

  2023-02-01

  

  To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su

• Song et al reported series of triazolylsalicylamide derivati

  2023-01-31

  

  Song et al. reported series of 1,2,3-triazolylsalicylamide derivatives and screened over kinase panel and found compound 31 as most potent which inhibited Aurora-A, specifically with IC50 of 0.37 μM. Compound 31 was about 10-fold more active for Aurora-A than for Aurora-B (IC50 = 3.58 μM reported se

• The MOB and AOB are important in ungulates Keller

  2023-01-31

  

  The MOB and AOB are important in ungulates (Keller and Levy, 2012, Sanchez-Andrade and Kendrick, 2009), which rely heavily on odorant information for social interactions (Baum and Cherry, 2015, Keller and Levy, 2012, Osada et al., 2014, Villagran and Ungerfeld, 2013). The release of GABA and glutama

• br Materials and methods br Results

  2023-01-31

  

  Materials and methods Results Discussion Recently, we showed that stimulation of TRPM3 and TRPC6 channels triggers a signaling cascade leading to the activation of AP-1 [11], [12], [13], [15]. The objective of this study was to investigate whether stimulation of TRPV1 channels leads to an a

• Recent work has detailed the impact of

  2023-01-31

  

  Recent work has detailed the impact of genetic 6-O-α-Maltosyl-β-cyclodextrin of AMPK in the liver, revealing only minor phenotypes upon removal in mice (Boudaba et al., 2018). However, these studies very elegantly showed the potential for small molecule-mediated activation of AMPK to elicit large

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