• br Conclusion These studies broadly

  2024-06-12

  

  Conclusion These studies broadly demonstrate that dopamine and endocannabinoid signaling in the NAc can have diverse effects on AMPAR-mediated synaptic function depending on previous psychostimulant experience. Here, we examined mechanisms underlying the depotentiation of AMPAR-mediated synaptic

• Alectinib is a second generation ALK

  2024-06-12

  

  Alectinib is a second generation ALK antagonist that is built upon a 9-ethyl-6, 6-dimethyl-11-oxo benzo[b]carbazole scaffold (Fig. 5C) [58]. This drug is effective against the ALK L1196M gatekeeper mutation along with C1156Y and F1174L mutations [7]. The 11-oxo group of the drug forms a Bestatin hyd

• Since the first studies of betaine

  2024-06-12

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other TH588 as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of attention whe

• br Current therapies for metabolic diseases

  2024-06-12

  

  Current therapies for metabolic diseases Inborn errors of metabolism caused by deficiency of particular enzymes due to loss of function mutations or deletions have been treated by decreasing the intake of the enzymatic substrate, supplementation with an essential cofactor or vitamin, increasing m

• OCT also is known as POU F plays an important

  2024-06-11

  

  OCT4 (also is known as POU5F1) plays an important role in embryonic stem cell self-renewal, development and reprogram somatic cell into pluripotent stem cell [[5], [6], [7]]. Recently, many studies also find OCT4 promotes the progression of many tumors. For example, Wnt/β-catenin promotes the expans

• br Results br Discussion The present study uncovers a

  2024-06-11

  

  Results Discussion The present study uncovers a role of calpain, a family of calcium-dependent protease, in regulating postsynaptic differentiation at the NMJ. Cholinergic activation stimulates calpain, whose inhibition stabilizes AChR clusters in cultured muscle DMOG and in agrin mutant mice

• Although effects of low concentrations of agonist were

  2024-06-11

  

  Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major inhibitor of catalase α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-ester

• Additionally regulation of GPCR heteromerization by specific

  2024-06-11

  

  Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut

• l Arginine supplementation was reported to be

  2024-06-08

  

  l-Arginine supplementation was reported to be efficient, inefficient or toxic in aged patients. The present study does not support our hypothesis that increased tissue arginase activity may account for the ineffectiveness and even the toxicity of l-arginine supplementation in ageing. Indeed, except

• To further address the mechanism of

  2024-06-08

  

  To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor PU-WS13 and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurring downstre

• br Materials and methods br Results br

  2024-06-08

  

  Materials and methods Results Discussion Recently, we showed that stimulation of TRPM3 and TRPC6 channels triggers a signaling cascade leading to the activation of AP-1 [11], [12], [13], [15]. The objective of this study was to investigate whether stimulation of TRPV1 channels leads to an a

• The proposed method was also used to evaluate

  2024-06-08

  

  The proposed method was also used to evaluate resistance to natamycin (a natural antibiotic produced by Streptomyces natalensis used for fungal control on cheese surface) of 9 fungi, including those previously mentioned as well as Phoma pinodella UBOCC-A-116004, Candida parapsilosis UBOCC-A-216002,

• The evaluation of serum electrolytes e g

  2024-06-08

  

  The evaluation of serum electrolytes (e.g.: sodium, potassium, urea, creatinine, and uric acid), liver transaminases, blood counts (e.g. identification of thrombocytopenia, and bilirubin), 24-h urine (in order to monitor proteinuria), and heart rate and lung function of the mother should be performe

• br Disclosure br Acknowledgments br Introduction Deeper unde

  2024-06-07

  

  Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small NPPB that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations in epidermal growth

• br Experimental section br Introduction Microglia

  2024-06-07

  

  Experimental section Introduction Microglia were discovered as a novel cell population in rsv virus in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer plexiform layer (OPL

14733 records 132/983 page Previous Next First page 上5页 131132133134135 下5页 Last page